The crop protection industry needs a reboot, according to Tony Klemm.
As CEO of Enko, a crop-protection startup, he says the company is taking a different approach to solving one of agriculture’s biggest problems – developing safe, effective and sustainable crop protection products that can be brought to the marketplace faster and more economically.
Traditional discovery pipelines for herbicides, fungicides, insecticides are not keeping pace with real challenges farmers face, such as resistance issues, he told Chip Flory, host of AgriTalk on Thursday.
A 2024 study funded by Crop Life International reports the costs associated with bringing a new active ingredient to major U.S. and European markets now top $300 million. In addition, the survey says the average lead time between the first synthesis of a new crop protection molecule and its subsequent commercial introduction is now over 12 years.
Part of the long development time required is related to regulatory hurdles. “There’s just increasing demand for meeting environmental safety needs, rightfully so,” Klemm says.
A Paradigm Shift
Enko, based in Mystic, Conn., is using artificial intelligence (AI) and a machine learning discovery platform to guide the company’s research and development efforts. Klemm describes the strategy as a paradigm shift from the current industry practices for how small molecule crop protection discovery has been done.
“We use DNA-encoded libraries, and these libraries allow our scientists to explore this massive, diverse chemical space in a very targeted, automated and expansive way,” he says.
The technology allows Enko scientists to look at billions of molecules and screen them for safety and efficacy and, in the process, develop them faster and more economically.
“We still have to take the regulatory journey that, right now, no one’s figured out a way to expedite,” he notes. “But getting to that regulatory queue faster and better on the front side is really what’s bringing us that cost savings, that efficacy and is going to allow for more products to be put into the regulatory queue in a faster manner.”
Progress To Date
So far, Klemm says Enko has delivered about 50 active programs that cover all facets of weeds, insects and disease. Many use novel or new modes of action that Klemm believes will help farmers fight resistance issues, such as herbicide resistance in Palmer amaranth and pigweed.
“We’re really working on how we can bring new modes of action to farmers, give them fresh tools to win that fight. And our chemistries work using fewer active ingredients, from perspective of the load on the acre, so we’re designing safer chemistry for the future,” he says.
Specifically, Klemm says Enko recently announced a new grass herbicide is in the pipeline for the European cereals market for control of black grass. The company also has conducted field trials for corn and soybean products in the U.S. that he anticipates are five to 10 years away from market launch, depending on how long they take to move through regulatory channels.
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